The <em>Portrait of Francesco delle Opere</em> is a painting by the Italian Renaissance artist Perugino, dating to 1494 and housed in the Uffizi Gallery, Florence. Francesco delle Opere is portrayed from three-quarters, with a black beret and a mantle of the same color, a red blouse under which is a white shirt. His hand holds a cartouche with the words Timete Devm ("Beware of God"), the beginning of a famous preaching by Girolamo Savonarola. The hands lie on an invisible parapet which coincides with the painting's lower border, as in Flemish contemporary works such as Hans Memling's Man with a Letter.